no correlation between interleukin-10 gene promoter polymorphisms and hepatitis b virus infection outcome
نویسندگان
چکیده
objectives this study evaluates the correlation between hbv infection and snp in il-10 gene promoter. patients and methods ninety-six hbv-infected patients (32 chronic hepatitis b infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. three biallelic (-819,-592,-1082) regions in the il-10 gene promoter were sequenced for all patients. results genotypes and haplotypes of il-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, hbv recovered cases, carriers and chronic hbv patients. nevertheless, a/a genotype at position -592 and t/t genotype at position -819 were more frequently seen in the hbv clearance group, while frequency of g/g genotype at position -1082 was more prevalent in the persistence group. gcc/gcc and gcc/acc haplotypes were significantly observed in anti-hbe positive individuals. conclusions our findings showed that il-10 promoter polymorphisms were not correlated with hbv infection prognosis. nevertheless, individuals carrying high and intermediate producer of il-10 haplotypes had a better ability to develop anti-hbe than low producer carriers. background single nucleotide polymorphisms (snp) in the promoter region of the interleukin (il)-10 genes have a role in determining hepatitis b virus (hbv) outcome.
منابع مشابه
No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
BACKGROUND Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome. OBJECTIVES This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter. PATIENTS AND METHODS Ninety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spon...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۳، شماره ۵، صفحات ۰-۰
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